AKT1 and hereditary clear cell renal cell carcinoma: KEGG enrichment analysis indicated that the target genes of curculigoside were mainly involved in proteoglycans in cancer, Rap1 signaling pathway, pathways in cancer, PI3K-Akt signaling pathway, Ras signaling pathway, HIF-1 signaling pathway, cytokine-cytokine receptor interaction, bladder cancer, and renal cell carcinoma (Fig. 2e).