The angiotensin-converting enzyme 2 (ACE2) receptor, the point of entry of SARS-CoV-2 and protective against hypertension and inflammation [21, 22], is strengthened by vitamin D via heightened expression that balances ACE/ACE2 and angiotensin II (ANG)/ANG 1–7, pathways that are known to be disrupted by coronaviruses [23]. This evidence concerns the gene ACE2 and hypertensive disorder.