LDHA and non-small cell lung carcinoma: Compared to previous studies, this manuscript provides clinical evidence that LDHA overexpression is highly associated with radioresistance and worse survival in NSCLC, and LDHA inhibition by oxamate suppressed glycolysis and reduced cellular ATP levels, shifted cell metabolism from glycolysis to mitochondrial oxidative phosphorylation (OXPHOS) and generated more ROS, which might increase DNA injury and hinder DNA repair activity.