To explore the effect of LDHA inhibition on the radiosensitivity of NSCLC, two NSCLC cell lines (A549 and H1975 cells) were pretreated with oxamate, one widely used inhibitor of LDHA as a structural analogue of pyruvate, and followed with the exposure to different doses of irradiation. Here, LDHA is linked to non-small cell lung carcinoma.