Among the pathways related to colon cancer, the potential pathways that are significantly related to the aloe-emodin target were identified; these pathways include Pathways in cancer, Colorectal cancer, Proteoglycans in cancer, PI3K-Akt signalling pathway, Prolactin signalling pathway, Neurotrophin signalling pathway, FoxO signalling pathway, and ErbB signalling pathway. This evidence concerns the gene PRL and malignant colon neoplasm.