investigated the role of PSMC2 in the development and metastasis of osteosarcoma, indicating the upregulation of PSMC2 in osteosarcoma tissues and elucidating the PSMC2 knockdown induced inhibition effects on cell proliferation, colony formation, cell motility and promotion of apoptosis as well as arrest of cell cycle in G2/M and/or S phase [23]. This evidence concerns the gene PSMC2 and osteosarcoma.