We found no significant difference between DCM and MMVD patients in TNF-α and CRP concentrations, WBC, NEUT, LYMPH, MONO and percentages of neutrophils, lymphocytes and monocytes, and MDA concentration; however, GPX activity was significantly higher in MMVD than in DCM patients (P = 0.003) and control dogs (P = 0.003). The gene discussed is CRP; the disease is familial dilated cardiomyopathy.