In addition, altered myocardial cytokine expression was demonstrated in dogs with systemic and end-stage cardiac disease compared with control dogs, and dogs with end-stage cardiac disease had significantly increased myocardial expression of interleukins (IL -1, IL -6, IL -8, IL -10), TNF-α, and interferon-gamma compared with dogs with systemic disease [28]. The gene discussed is TNF; the disease is heart disorder.