Reports indicate that genes include SPHK2 [82], NPC1L1 [83], CNTFR (ciliaryneurotrophic factor receptor) [84], SLC2A4 [85], EDA (ectodysplasin A) [86], TGM2 [87], GCK (glucokinase) [88], FASN (fatty acid synthase) [89], FAP (fibroblast activation protein alpha) [90], PRNP (prion protein) [91], LYVE1 [92], SERPINE1 [93], TNF (tumor necrosis factor) [94], FASLG (Fas ligand) [95], HGF (hepatocyte growth factor) [96], FNDC5 [97], LBP (lipopolysaccharide binding protein) [98] and LOX (lysyl oxidase) [99] were the genes expressed in obesity associated type 2 diabetes mellitus. The gene discussed is PRNP; the disease is type 2 diabetes mellitus.