Genes such as CACNA1A [105], ALK (ALK receptor tyrosine kinase) [106], SLC4A4 [107], STOX1 [108], COL3A1 [109], VNN1 [110], SLC4A7 [111], BDKRB2 [112], DRD1 [113] and LPAR1 [114] have reported significantly linked with hypertension, but these genes might be crucial for progression of obesity associated type 2 diabetes mellitus. The gene discussed is SLC4A4; the disease is obesity due to melanocortin 4 receptor deficiency.