10 hub genes, including CEBPD, TP73, ESR2, TAB1, MAP 3K5, FN1, UBD, RUNX1, PIK3R2 and TNF, were identified as the key genes responsible for progression of obesity associated type 2 diabetes mellitus. The gene discussed is CEBPD; the disease is obesity due to melanocortin 4 receptor deficiency.