MAP 1B, hsa-mir-4314, hsa-mir-5688, hsa-mir-583, hsa-mir-632, hsa-mir-3176, hsa-mir-4477a, hsa-mir-606, hsa-mir-1343-3p6, SIN3A, ZNF143 and SMARCE1 are the novel biomarkers for pathogenesis of obesity associated type 2 diabetes mellitus. Here, ZNF143 is linked to obesity due to melanocortin 4 receptor deficiency.