In conclusion, with the integrated bioinformatics analysis for expression profiling by high throughput sequencing in obesity associated type 2 diabetes mellitus, ten hub genes associated with the pathogenesis and prognosis of obesity associated type 2 diabetes, including CEBPD, TP73, ESR2, TAB1, MAP 3K5, FN1, UBD, RUNX1, PIK3R2 and TNF. This evidence concerns the gene ESR2 and obesity due to melanocortin 4 receptor deficiency.