Eberlé et al [165], Cheng et al [166], Cavallari et al [167], Qi et al [168] and Yan et al [169] indicated that SREBF1, MBD2, IRF4, CREB1 and RELA (Nuclear factor-kB) were the genes responsible for advancement of obesity associated type 2 diabetes mellitus. Here, RELA is linked to obesity due to melanocortin 4 receptor deficiency.