NOTCH3 and cancer: The functional enrichment analysis results showed that some KD genes were enriched in apoptosis-associated (such as “Programmed cell death” and “Apoptosis-related network due to altered Notch3 in cancer”) and immune-associated functions (such as “Antigen processing: Ubiquitination & Proteasome degradation”), which were related to the corresponding cancer hallmarks, “Evading Apoptosis”, “Evading Immune Detection” and “Tumour Promoting Inflammation”, respectively.