In addition, the down-regulation of GPC-4 at the mRNA level suggested a better OS in the grade (II), AJCC_T (III) subgroup (HR = 1.69, 95% CI = 1.01–2.83, P = 0.0435; HR = 1.99, 95% CI = 1.04–3.83, P = 0.0343, Fig. 9b-c), whereas it indicated a worse OS in Caucasian HCC patients (HR = 1.56, 95% CI = 0.35–0.91, P = 0.0167, Supplemental Table 2). Here, GPC4 is linked to hepatocellular carcinoma.