To date, GPC-3 is the most well-documented GPC gene in its family in different cancers, including HCC, ovarian clear cell carcinoma, melanoma, squamous cell carcinoma of the lung, hepatoblastoma, nephroblastoma (Wilms tumor), yolk sac tumor, and some pediatric cancers [36]. This evidence concerns the gene GPC3 and squamous cell lung carcinoma.