Of all three studied biomarkers, IL-6 showed the weakest diagnostic value for sepsis, with a pooled sensitivity of 0.72 (95% CI, 0.65–0.78), the pooled specificity of 0.70 (95% CI, 0.62–0.76), and AUC of 0.77 (95% CI, 0.73–0.80). This evidence concerns the gene IL6 and Sepsis.