Among the signaling pathways identified and which have been already documented to correlate with GBM biology, we highlight the angiogenesis, cadherin signaling pathway, epidermal growth factor (EGF) receptor signaling pathway, hypoxia response via HIF activation, Notch signaling pathway, PI3 kinase pathway, vascular endothelial growth factor (VEGF) signaling pathway, Wnt signaling pathway and p53 pathway (Additional file 6). This evidence concerns the gene VEGFA and glioblastoma.