Furthermore, CENPU was markedly upregulated in patients with lymph node metastasis (Figure 2D), as well as in estrogen receptor (ER)-negative (Figure 2E), progesterone receptor (PR)-negative (Figure 2F), and human epidermal growth factor receptor 2 (HER2)-positive breast carcinoma patients (Figure 2G). This evidence concerns the gene ESR1 and breast carcinoma.