Also, GeneMANIA analysis revealed that PRDM1, PNKP, RFX3, TIFAB, FHAD1, SLMAP, TIFA, CEP170, CEP170B, MCRS1, PPP1R8, SNIP1, APTX, FOXK1, FOXK2, CHFR, SMAD6, APLF, RNF8, and SMAD4 were primarily associated with the modulation and function of IRF genes in glioma (Figure 5F). Here, SMAD4 is linked to central nervous system cancer.