Also, GeneMANIA analysis revealed that PRDM1, PNKP, RFX3, TIFAB, FHAD1, SLMAP, TIFA, CEP170, CEP170B, MCRS1, PPP1R8, SNIP1, APTX, FOXK1, FOXK2, CHFR, SMAD6, APLF, RNF8, and SMAD4 were primarily associated with the modulation and function of IRF genes in glioma (Figure 5F). This evidence concerns the gene SMAD6 and glioma.