Also, GeneMANIA analysis revealed that PRDM1, PNKP, RFX3, TIFAB, FHAD1, SLMAP, TIFA, CEP170, CEP170B, MCRS1, PPP1R8, SNIP1, APTX, FOXK1, FOXK2, CHFR, SMAD6, APLF, RNF8, and SMAD4 were primarily associated with the modulation and function of IRF genes in glioma (Figure 5F). The gene discussed is RNF8; the disease is glioma.