After correcting for confounding factors, we found that B cells (p = 0.002), CD8+ T cells (p = 0.042), IRF1 expression (p = 0.001), and IRF8 expression (p = 0.000) were significantly associated with the prognosis of LGG patients, while CD4+ T cells, dendritic cells (p =0.002), IRF1 expression (p = 0.01), IRF7 expression (p = 0.007), and IRF8 expression (p = 0.028) were associated with the prognosis of GBM patients (Table 3). The gene discussed is IRF8; the disease is glioblastoma.