However, at three loci (2q12.1, 14q13.2, and 20q13.33), there may be tissue-dependent effects on expression, with opposite directions of effect on STMN3, LIME1, APFRP1, IL18RAP, and PP2R3C. This indicates that causal variants potentially reside in tissue type‒specific regulatory regions and that the context-dependent effect of these genes could impact AD phenotype. This evidence concerns the gene LIME1 and Alzheimer disease.