The importance of Jak‒STAT signaling has recently been highlighted by its enrichment among genes prioritized for inflammatory skin diseases (including AD) with Hi-chromatin immunoprecipitation‒derived T-cell enhancer connectome (Jeng et al., 2019) and over-representation of rare coding variants in Jak1 and/or Jak2 in a new AD study (Mucha et al., 2020). Here, JAK2 is linked to Alzheimer disease.