Accordingly, several mutations of the CB gene (ARHGEF9; Online Mendelian Inheritance in Man number: 300429) in patients have been implicated in epilepsy, X-linked intellectual disability, aggressive behavior, anxiety and, in one case, with hyperexplexia (29, 30, 31, 34, 35, 42, 78). The gene discussed is ARHGEF9; the disease is epilepsy.