Amongst patients with lipodystrophy and idiopathic SIR, fasting insulin and SHBG were negatively associated (rs = –0.291, P = 3.58 × 10–04 and rs = –0.554, P = .0113, respectively), whereas a positive association between these 2 variables was seen among patients with insulin signaling disorders (rs = 0.551, P = 7.21 × 10–05) (Fig. 2H), potentially explaining this discrepancy. This evidence concerns the gene INS and lipodystrophy.