Among patients with lipodystrophy, 45% (67/150) and 1.3% (2/150) had an SHBG level below or above the normal range, respectively; these proportions were 8% (4/49) and 27% (13/49) among patients with insulin signaling disorders, and 52% (11/21) and 0% (0/21) among patients with idiopathic SIR (Fig. 2E). The gene discussed is INS; the disease is lipodystrophy.