Treated from age 8 with leptin, high-dose insulin (900 units/day) and metformin. At age 19, amenorrheic with extensive hirsutism, hyperandrogenemia and bilaterally enlarged multicystic ovaries on pelvic ultrasound. Bilateral oophorectomy for hyperandrogenism. Testosterone undetectable after 8 months. This evidence concerns the gene INS and hyperandrogenism.