Hair growth on chin, back, and chest age 12. Diabetes age 14, with worsening hirsutism, cystic acne (face and chest) and clitoromegaly (clitoral length 4 cm, index 42 mm2, normal <35 mm2). No improvement after metformin. 22.5 mg intramuscular leuprolide acetate administered age 15, after which testosterone levels decreased. No change in HbA1c after 6 months (insulin was not measured). Lost to follow up. The gene discussed is INS; the disease is diabetes mellitus.