See Table 2 for history prior to oophorectomy. Persistent virilization, hirsutism, and amenorrhea aged 23 (4 years post unilateral oophorectomy). Daily subcutaneous injections of leuprolide initiated. Serum testosterone improved but remained elevated. Underwent completion oophorectomy 5 years after GnRH initiation. This evidence concerns the gene GNRH1 and Hirsutism.