On the other hand, let-7a-5p was associated with pathways related to cancer, such as TGF-β, thyroid hormone signaling, transcriptional mis-regulation, other pathways in cancer, colorectal carcinoma, chronic myeloid leukemia, Hepatitis B, endocytosis and viral carcinogenesis (Table 7 and S6 Fig). This evidence concerns the gene TGFB1 and hepatitis B virus infection.