As the most common kind of neurodegenerative disorder among various NDDs, Alzheimer’s disease (AD) displays such typical pathology including the deposition of extracellular cortical plaques formed by aggregation of β-amyloid protein (Aβ) and intracellular neurofibrillary tangles caused by hyperphosphorylation of Tau protein [1]. This evidence concerns the gene MAPT and Alzheimer disease.