AKT1 and gastric cancer: Furthermore, our data also suggested cell cycle was arrested at G0/G1 phase and cell apoptosis was promoted in GC cells overexpressing hsa_circRNA_100269, where the expression levels of PI3K/Akt-associated molecules were also affected, suggesting the biological behavior changes in GC cells caused by hsa_circRNA_100269 could be dependent on the PI3K/Akt signaling.