Age (HR, 1.045; 95% confidence internal [CI], 1.012–1.079; p = 0.007), PSA (HR, 1.277; 95% CI, 1.136–1.435; p<0.001), Del-1 protein (HR, 22.935; 95% CI, 2.248–234.001; p = 0.008) were independent prognostic factors for predicting significant PCa. The gene discussed is KLK3; the disease is posterior cortical atrophy.