Since 2008, numerous studies were conducted to investigate the function of Del-1 such as homeostatic factor in the central nervous system by limiting neuro-inflammation and demyelination [14], inhibitor of ischemia related angiogenesis by blocking inflammation [15], inhibitory factor for preventing peritoneal adhesion [16] and biomarker of endothelial dysfunction, sepsis, and sepsis induced organ dysfunction [17]. The gene discussed is EDIL3; the disease is endothelial dysfunction.