KLK3 and posterior cortical atrophy: To overcome these drawbacks of PSA, numerous biological markers have being developed to enhance the specificity of PCa screening such as free PSA, prostate health index, 4K score, prostate cancer antigen 3, SelectMDx®, ConfirmMDx®, TMPRSS2:ERG GENE FUSION, and ExoDx PROSTATE INTELLISCORE [4, 5].