PGP and Familial prostate cancer: To test whether we could observe the results of transport of Aβ42 by P-gp in human cellular systems, a fluorescently labeled Aβ42 peptide (HiLyte488-Aβ42) was assayed for accumulation in the paired DU145 and DU145-TXR prostate cancer cell lines [30, 52, 53].