Figure 5C shows that upregulation of miR-107 induced cell apoptosis both in HA22T and HDACi-R tumors. Moreover, we also obtain that upregulation of miR-107 decreased survival protein (p-Akt) and CFL-1 expression both in two HCC tumors (Figure 5D). This evidence concerns the gene AKT1 and hepatocellular carcinoma.