This reversal was not seen in the mice with KCNQ2 overexpression in the VTA-to-mPFC DA neurons (Fig. 5G), These results indicate that functional modulation of KCNQ2 channels in the VTA-to-NAc, rather than the VTA-to-mPFC circuit contributes to regulating thermal nociception in chronic neuropathic pain. Here, KCNQ2 is linked to Pain.