Its kinetic parameters contrast agent efflux transfer constant (Ktrans), contrast agent reflux transfer constant (kep), the extracellular-extravascular volume fraction (ve) and the intravascular volume fraction (vp), a suspected correlate for vascular space, were shown to correlate with glioma WHO grades, genomic prognostic markers, microvascular anatomy such as vessel density, as well as VEGF expression [2, 3, 7, 13–18]. The gene discussed is VEGFA; the disease is glioma.