PTPRB and central nervous system cancer: Glioma vascularization can be assessed on a molecular level, e.g. through the analysis of expression of vascular endothelial growth factor (VEGF) the VEGF receptors (VEGFR) or vascular endothelial-protein tyrosine phosphatase (VE-PTP), which is associated with BBBD, as well as histologically studying microvessel density or presence of enlarged vessels (ESM 1) [5].