MOG and multiple sclerosis: Multiple sclerosis was overrepresented among patients with false-positive results, which should dissuade clinicians from uniform ordering of MOG-IgG1 testing in patients with typical MS.9 Prior studies12,13,14 have shown a lower frequency of MOG-IgG1 positivity via live cell–based assays among patients with MS (0%-2% vs 2.5% in our study), possibly from differences in assay cutoff values, inclusion criteria, or referral bias.