PPARG and Hepatic steatosis: In addition to regulating cholesterol homeostasis, NR1H3 induces the hepatic transcription of several lipogenic enzymes.24 PPAR-γ is also well known target for antidiabetic drugs such as thiazolidiniones.25 Thus, future studies of HFD feeding of longer duration (e.g. 12 weeks) should investigate the effect of the formulation on markers of hepatic steatosis and improvement in glucose homeostasis.