SLC26A5 and sensorineural hearing loss disorder: Similarly, in 5-week-old wild-type, CBA/CaJ mice with diphtheria toxin-induced SNHL (intraperitoneal injections of diphtheria toxin, 50 ng/g for 3 days in a row) prestin up-regulation seems to be locally regulated by the steady state transducer bias current with no involvement of centrally mediated efferent feedback (Roux et al. 2006; Song et al. 2015).