Sun et al. (2020) included patients hospitalized with ISSHL. Hana and Bawi (2018) evaluated prestin blood levels in patients with NIHL. Animal studies included rats and guinea pigs that were exposed to ototoxic substances, such as aminoglycosides and cisplatin (Liba et al. 2017; Dogan et al. 2018; Naples et al. 2018), and thus present SNHL due to ototoxicity; or to hazardous levels of noise, and thus present NIHL (Parham & Dyhrfjeld-Johnsen 2016; Parham et al. 2019). The gene discussed is SLC26A5; the disease is noise induced hearing loss.