Furthermore, our high-throughput proteomic approach reveals comparable expression of proteins belonging to specific pathways that regulate cancer development and also anti-tumor immune responses, e.g., PD-L1, MHC-I, TGF-β, HLA-1, HSP70 and −90, CD276, CD58 and calreticulin in EVs from both irradiated and control CAFs. The gene discussed is CD58; the disease is cancer.