Second, mouse models have shown that altering the expression of several factors, including ectopic expression of ERG, SPI1, or FLI1 or reduced expression of GATA1 can induce AEL phenotypes, indicating that additional mechanisms converging on GATA1 lead to the development of erythroid leukemia.50,52,85,93 In the line of these observations in mice, we found that aberrantly high expression of several proteins that impact GATA1 function are recurrent alterations in human primary AEL cells. Here, GATA1 is linked to acute erythroid leukemia.