NSD1 and cancer: Multiple genes encoding for these epigenetic regulators are targets of recurrent somatic gene alterations that have been shown to contribute to AML initiation and maintenance.122 H3K36me3 is the product of mono- and dimethylation by the nuclear receptor interacting SET domain (NSD)1–3 family, ASH1L, or SETMAR followed by SETD2-mediated trimethylation.123 NSD1 is the target of recurrent genomic alterations in human cancers.