GATA1 and leukemia: Another chromatin modifier that has also been recently found to interact with GATA1 and other components of the GATA1-transcriptional complex is the KDM5A histone H3K4me demethylase.165 Notably, NUP98-KDM5A fusions have been found in pediatric AMKL and AEL patients.19,35 Although the ectopic expression of this fusion in human cord blood HSPC lead to immortalization and multilineage leukemia when injected in mice its impact on the chromatin and on GATA1 activity remains unknown.166