TFRC and T-cell leukemia: Similar to the observation by Seto, some mice developed CD4+/CD8+ T-cell leukemia, others developed nonlymphoid disease composed of CD71+/Ter119+/− cells in some, but also CD71+/CD41+ cells in other mice.85 Collectively, these studies suggest that abnormally high ERG expression contributes to hematopoietic malignancies affecting the erythromegakaryoblastic and T-cell lineage.