Similar to previous studies, retroviral Cdx4 overexpression provided aberrant serial replating potential to BM-derived hematopoietic cells.57,91 Notably, mice transplanted with Cdx4 virally transduced BM-derived HSPC developed a transplantable erythroleukemia-like disease after a long latency, characterized by anemia, splenomegaly with infiltration of CD71+Ter119+/− erythroid progenitors, occasionally erythroid progenitors in the periphery, and multiorgan infiltrations upon propagation into secondary recipients. The gene discussed is CDX4; the disease is Splenomegaly.