NFE2 and erythroleukemia: Erythroleukemia in the mice was characterized by aberrant expression of erythroid developmental regulators such as Gata1, Kruppel-like factor 1 (Klf1), or Nuclear factor erythroid-2 (Nfe2), driven by the interaction of mutations of the epigenetic modifiers Dnmt3a and Tet2 that perturbed methylation and thus expression of lineage-specific transcription factors.