NOTCH3 and infantile myofibromatosis: Using the DUET server,25 the A1604T mutation has a predicted stability change of −1.7 kcal/mol, a decrease similar to that observed for 2 other previously described missense mutations in the NOTCH3 HD region: the L1515P mutation linked to SVD (−2.4 kcal/mol) and the L1519P mutation linked to infantile myofibromatosis (−1.79 kcal/mol)31, -, 33 (figure 6A).