The major results of the study showed that IL-10 negatively adjusts angiogenesis induced by ischemia, and ticagrelor inhibits the angiogenesis and blood reperfusion recovery, significantly increases IL-10 level, and reduces the VEGF expression in the IL-10+/+ mouse ischemic hindlimb, which were abolished in IL-10−/− mice. This evidence concerns the gene IL10 and ischemia.