Liu et al. (78) observed previously that infection of MDBK cells with a type 1b ncp strain of BVDV (BJ-2016, derived from commercial bovine fetal serum) caused downregulation of ISG15, MX1, and OSA1Y together with a number of genes which form part of the complement and coagulation signaling cascades. This evidence concerns the gene ISG15 and infection.