Apart from two known genes, KMT2D and NOTCH1, we reported a potential pathogenic gene WDFY3, and this is the first case of a fetal CHD with a frameshift variant in WDFY3. Before this genetic variant is used to genetic counseling, more sequencing data and functional studies are needed to determine the contribution of this genetic variant to CHDs. The gene discussed is KMT2D; the disease is coronary artery disorder.