Interestingly, two well-known pathways were detected, including the P53 signaling pathway that was associated with the tumorgenesis and immune formation of CRC and the ECM-receptor interaction pathway that was significantly associated with the formation of the tumor microenvironment (Cho et al., 2020; Yin et al., 2020; Chen Y. et al., 2020; Zou et al., 2019). Here, TP53 is linked to neoplasm.