In both human and mouse genomes, the Foxq1 gene is located directly upstream of Foxf2. Previous studies using breast cancer cell lines have suggested that FOXF2 and FOXQ1 have opposite functions in regulating epithelial-mesenchymal transition and that they repress the expression of each other (Zhang et al., 2011; Wang et al., 2015; Kang et al., 2019). This evidence concerns the gene FOXF2 and breast cancer.