In our data, specifically for OPFRCs, reduced expression of mir-125b was associated with increased expression of BCL2 and TP53 (anti-apoptotic genes), ERBB2 (an androgenic gene) as well as CYP24A1 and VDR (Figure 5B); negative correlations of mir-125b with all of the aforementioned genes have been previously evidenced in several cancer types (Mohri et al., 2009; Banzhaf-Strathmann and Edbauer, 2014; Wang et al., 2020). The gene discussed is CYP24A1; the disease is cancer.