Consistently, a recent study linked PATZ1 to neuron and glia differentiation through its interaction with the variant polycomb repressor complex 1 component PCGF1, which also interacts with NANOG and OCT4, and contribute to the maintenance of the undifferentiated phenotype of NT2 teratocarcinoma cell line that, upon treatment with all-trans retinoic acid, can differentiate to both neuron and glia (Oliviero et al., 2015). Here, POU5F1 is linked to teratocarcinoma.