ATF4 and cardiovascular disorder: Moreover, concerning the fact that moderate control and reduction of salt intake can ameliorate the high-salt diet-induced risk of cardiovascular disease (Wilson et al., 2019), we also suggested Yan et al. to consider switching the mice to a normal diet after a 4-week high-salt diet, and then observing whether the altered ATF4 expression and intestinal flora could return to normal status, so as to determine the changes of ATF4 and intestinal flora caused by high salt diet are either reversible or irreversible.