ESR2 and neoplasm: In particular, our published work identified a subtype-specific phosphotyrosine residue in human ERβ Y36 that regulates its tumor-intrinsic (Yuan et al., 2014, 2016) and -extrinsic (Yuan et al., 2021) antitumor activity, which underscores an ER subtype-specific regulatory mechanism via tyrosine phosphorylation.