ALS reduced the expressions of HDAC4 and HDAC5 in HSVECs, while it increased the expressions of HDAC3, HDAC4, HDAC5, phosphorylated (p)-HDAC3, and p-HDAC4/5/7 in HUVECs (Figure 2D). The gene discussed is HDAC3; the disease is amyotrophic lateral sclerosis.