ZEB1 and Familial prostate cancer: In addition to loss-of-function gene mutation, our recent studies also indicate that elevated expression of zinc finger E-box binding homeobox 1 (ZEB1), an important epithelial-to-mesenchymal transition related transcription factor, in prostate basal stem cells which is associated with the formation of CSCs in the prostate promotes androgen independence of prostate cancer (Wang X. et al., 2020).