A key study has given evidences that in glioblastoma stem cells (GSCs) elevated expression of Achaete-Scute Complex-Like 1 (ASCL1) can promote the proliferation of quiescent cells and their differentiation into neurons by binding the chromatin at enhancer region of the neural target genes to activate the transcription of these target genes, including NK6 homeobox 2 (NKX6-2), high mobility group AT-hook 2 (HMGA2), G protein-coupled receptor 37-like 1 (GPR37l1) and myelin transcription factor 1 (MYT1). Here, NKX6-2 is linked to glioblastoma.