BGN and glioblastoma: In addition, a more recent study shows that plant homeodomain finger-containing protein 20 (PHF20) is a crucial epigenetic regulator for sustaining the stem cell-like phenotype in GBM via regulation of the degradation of β-catenin in a WNT1 inducible signaling pathway protein 1 (WISP1)/biglycan (BGN) pathway dependent manner (Ma et al., 2020).