NCOA2 and cancer: Specifically, SRC-2 is required for progesterone-induction of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 (PFKFB3; Figure 4B), a bifunctional enzyme that is indispensable for a myriad of cellular processes from embryogenesis, post-natal cellular proliferation to cancer progression (Chesney et al., 2005; Chesney, 2006; Clem et al., 2008).