AQP4 and neuromyelitis optica: Indeed, experimental rodents lacking CD59 display enhanced demyelination in both experimental autoimmune encephalomyelitis (Mead et al., 2004) and the Aquaporin 4-IgG injection model of neuromyelitis optica (Zhang and Verkman, 2014; Yao and Verkman, 2017), in agreement with the view that CD59-expression protects against complement-mediated degeneration (Piddlesden and Morgan, 1993; Kolev et al., 2010).