TGFB1 and metastatic malignant neoplasm: Manipulation of the TGFβ1 pathway maybe a viable option for the treatment of both HMB and RPL in women who wish to preserve their fertility, especially as the development of TGFβ1 pathway modulators is already being explored for the treatment of metastatic cancer, with the possibility of repurposing of these therapeutics for the treatment of women with HMB and/or RPL, although any treatment in the latter group would need to be pre-pregnancy.