Indeed, p53 also plays a role in Hedgehog-dependent tumorigenesis: mouse models suggest that the loss of p53 may be associated to increased frequency of Hh-dependent tumorigenesis (Wetmore et al., 2001), and TP53 mutations are enriched among SHH medulloblastomas (Zhukova et al., 2013). Here, TP53 is linked to medulloblastoma.