Of note, reduced KCASH2 expression (and its related protein KCASH1) has been described in Hh-dependent tumors (De Smaele et al., 2004, 2011; Di Marcotullio et al., 2004), while KCASH2 expression in tumor cells leads to inhibitions of Hh signaling and reduction of tumor cell proliferation (De Smaele et al., 2011; Spiombi et al., 2019). The gene discussed is KCTD21; the disease is neoplasm.