However, the evidence demonstrated that the analyzed anxiety- and depression-related DEGs such as Gria1 (Rivera et al., 2020), Mapk1 (Sierra-Fonseca et al., 2019), Mapk9 (Thomson et al., 2020), and Fkbp5 (Zannas et al., 2019) contributed to anxiety or depression symptoms in rodents. The gene discussed is MAPK1; the disease is major depressive disorder.