Interestingly, among the anxiety- and depression-related DEGs, we found the upregulation of Bcl3, C3, Gpat3, and Tnf in the AMY as well as the increased expression of Crhr2, Nant, Sar1a, and Tgif1 and the decreased expression of Ier2, Il12a, Nrep, and Tnfrsf25 in the ACC. The gene discussed is IER2; the disease is depressive disorder.