TNF and type 2 diabetes mellitus: Consistent with previous reports (Jiang et al., 2015; Wu et al., 2016), GO term and KEGG pathway enrichment analyses in three regions showed notable enrichments in apoptotic, inflammation, immunity, cytokine production and defense response, behavior, and sensory perception of pain as well as the enrichments in chemokine signaling pathway, MAPK signaling pathway, TNF signaling pathway, cAMP signaling pathway, Type II diabetes mellitus, and T cell receptor signaling pathway.