RNF8 and nasopharyngeal carcinoma: Moreover, RNF8 (ring finger protein 8) protein catalyzes the mono-ubiquitination of histones H2A and H2B during DNA damage, thereby facilitating DNA damage repair and activation of cell cycle checkpoint (Kolas et al., 2007; Ma et al., 2011); RNF8 is associated with radioresistance in human nasopharyngeal cancer cells (Wang et al., 2015).