STAT3 and breast cancer: Moreover, NFKB1, together with the inflammatory factors HIF1A (hypoxia-inducible factor 1) and STAT3, both of which were found to be up-regulated in radioresistant breast cancer cells (Table 1) and HIF1A overexpressed in breast cancer tissue (Supplementary Figure 2), are critically implicated in cancer radioresistance and radiation-induced inflammatory responses (Multhoff and Radons, 2012).