In conclusion, we first elucidated that miR-494 was reduced in Exo-c-Jun-KO and Exo-SP, resulting in elevation of PTEN expression and down-regulation of Akt pathway in Exo-c-Jun-KO and Exo-SP treated HUVECs, which might contribute to the suppression of tumor angiogenesis. This evidence concerns the gene PTEN and neoplasm.