EGFR and lung cancer: Besides p.T790M, the pathogenic germline EGFR exon20 p.R776H and p.V769M identified in our cohort have also been reported in sporadic lung cancer cases (23, 24); whereas pathogenic germline mutations MET exon16 p.H1094R, RET exon14 p.V804M and p.V804L, and likely pathogenic EGFR exon20 p.G719D are reported in lung cancer for the first time.