Basic laboratory parameters, such as the blood neutrophil-to-lymphocyte ratio (NLR), blood hemoglobin, blood platelet counts, serum C-reactive protein (CRP), serum creatinine, and serum GPT were similar among the two groups, with the notable exception of serum lactate dehydrogenase (LDH), which was increased in patients with de novo compared to secondary metastatic disease (mean 295 vs. 228 U/l, p = 0.006, Figure 1C and Supplementary Table 2). This evidence concerns the gene CRP and metastatic neoplasm.